Claude G Wasterlain Selected Research

Status Epilepticus (Complex Partial Status Epilepticus)

12/2021	Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman-induced epileptogenesis and brain pathology in rats.
1/2020	Rational polytherapy in the treatment of cholinergic seizures.
12/2019	Early polytherapy for benzodiazepine-refractory status epilepticus.
12/2019	Dataset of EEG power integral, spontaneous recurrent seizure and behavioral responses following combination drug therapy in soman-exposed rats.
8/2017	Simultaneous triple therapy for the treatment of status epilepticus.
7/2017	Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury.
1/2017	Treatment of experimental status epilepticus with synergistic drug combinations.
2/2016	Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups.
1/2016	Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits.
1/2016	Benzodiazepine-refractory status epilepticus: pathophysiology and principles of treatment.

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Claude G Wasterlain Research Topics

Disease

31	Status Epilepticus (Complex Partial Status Epilepticus) 12/2021 - 01/2002
15	Seizures (Absence Seizure) 01/2020 - 01/2002
7	Necrosis 07/2010 - 01/2002
4	Epilepsy (Aura) 08/2010 - 01/2002
2	Hypothermia 12/2015 - 08/2015
1	Drug-Related Side Effects and Adverse Reactions 01/2017
1	Brain Injuries (Brain Injury) 02/2016
1	Inflammation (Inflammations) 12/2015

Drug/Important Bio-Agent (IBA)

9	Anticonvulsants (Antiepileptic Drugs)IBA 01/2016 - 01/2002
9	Pilocarpine (Ocusert)FDA LinkGeneric 08/2015 - 02/2002
8	Cholinergic Agents (Cholinergics)IBA 12/2021 - 10/2011
8	LithiumIBA 08/2015 - 02/2002
7	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 12/2021 - 12/2008
5	Caspase 3 (Caspase-3)IBA 07/2010 - 03/2003
4	BenzodiazepinesIBA 12/2021 - 01/2016
4	gamma-Aminobutyric Acid (GABA)IBA 12/2021 - 01/2005
4	Midazolam (Versed)FDA LinkGeneric 08/2017 - 08/2015
3	Ketamine FDA LinkGeneric 08/2017 - 01/2016
3	N-Methylaspartate (NMDA)IBA 09/2013 - 12/2008
3	GABA-A Receptors (GABA(A) Receptor)IBA 10/2011 - 08/2005
3	CaspasesIBA 07/2010 - 06/2007
2	Glutamate Receptors (Glutamate Receptor)IBA 01/2020 - 12/2019
2	Valproic Acid (Depakote)FDA LinkGeneric 08/2017 - 01/2017
2	Diazepam (Valium)FDA LinkGeneric 01/2017 - 02/2004
2	Proteins (Proteins, Gene)FDA Link 03/2003 - 03/2002
2	GalaninIBA 10/2002 - 01/2002
2	Dynorphins (Dynorphin)IBA 10/2002 - 01/2002
2	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 10/2002 - 01/2002
2	NeuropeptidesIBA 10/2002 - 01/2002
2	Neuropeptide YIBA 10/2002 - 01/2002
1	AcidsIBA 12/2021
1	SomanIBA 12/2019
1	fosphenytoin (Cerebyx)FDA LinkGeneric 08/2017
1	Phenobarbital (Luminal)FDA Link 07/2017
1	Aminobutyrates (Aminobutyric Acid)IBA 01/2017
1	Drug CombinationsIBA 01/2017
1	Nerve AgentsIBA 01/2016
1	Neuroprotective AgentsIBA 12/2015
1	fluoro jadeIBA 12/2015
1	Lacosamide FDA Link 03/2011
1	Adenosine Triphosphate (ATP)IBA 12/2010
1	Flurothyl (Flurotyl)IBA 12/2010
1	Phosphocreatine (Neoton)IBA 12/2010
1	Glucose (Dextrose)FDA LinkGeneric 12/2010
1	Lactic Acid (Lactate)FDA LinkGeneric 12/2010
1	(9H- fluoren- 9- yl)methyl(1- ((6- (tert- butoxycarbonyl)amino- 1- ((4- methyl- 2- oxo- 1,2- dihydroquinolin- 7- yl)amino)- 1- oxohexan- 2- yl)amino)- 3- cyclohexyl- 1- oxopropan- 2- yl)carbamateIBA 08/2010
1	Galanin Receptors (Galanin Receptor)IBA 08/2010
1	A-factor (Streptomyces)IBA 07/2010
1	quinoline-val-asp(OMe)-CH2-OPHIBA 07/2010
1	Calbindin 1IBA 07/2010
1	Kainic Acid (Kainate)IBA 06/2010
1	Pentylenetetrazole (Metrazol)IBA 06/2010
1	BicucullineIBA 06/2010
1	imidazole mustard (BIC)IBA 06/2010
1	Pharmaceutical PreparationsIBA 02/2006
1	Topiramate (Topamax)FDA LinkGeneric 02/2006
1	Cytochromes c (Cytochrome c)IBA 01/2005
1	Levetiracetam (Keppra)FDA LinkGeneric 02/2004
1	2-fluoro-2-phenyl-1,3-propanediyl dicarbamateIBA 10/2002
1	Felbamate (Felbatol)FDA Link 10/2002
1	Messenger RNA (mRNA)IBA 03/2002
1	PlasticsIBA 01/2002
1	CytochromesIBA 01/2002

Therapy/Procedure

2	Therapeutics 08/2017 - 01/2016
1	Rewarming 12/2015